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There are no clinical studies that clearly demonstrate that there are any known side effects of Glucosamine. The same is true of Chondroitin Sulfate which is often found in Glucosamine formulas.
At least one clinical study suggested that Glucosamine may alter blood sugar, insulin or hemoglobin levels. However, other studies have found no such relationship between Glucosamine and blood sugars and/or hemoglobin levels. Hemoglobin levels are a “measure” of how well blood sugar levels are controlled. At least in those studies involving humans, the use of Glucosamine has been found to be well tolerated by the body at least in the short term.
And although there are some side effects that are occasionally reported from using Glucosamine, it appears to be a result of over-dosing. These glucosamine side effects may include upset stomach; nausea; constipation; diarrhea or vomiting. Again, these appear to be extremely rare reports. And even when reported, they tended to resolve quickly.
There have been some reports of increased risk of bleeding for those who are taking warfarin or similar medications. Also, for those who take gingko biloba, garlic, vitamin E or clover. If you are taking these supplements and wish to use Glucosamine you should discontinue the use of them. If you are under a doctor’s care you should inquire about discontinuing any medication that has been prescribed for you.
In conclusion, it would appear that Glucosamine side effects are very low, and the product is safe and effective for its intended use with very few exceptions.